See MS section.
Optic Neuritis
Acute disseminated encephalomyelitis (ADEM)
Acute hemorrhagic leukoencephalitis (AHLS)
Neuromyelitis optica (Devic’s disease)
Primary CNS vasculitis
Secondary CNS vasculitis
|
HUS |
HSP |
TTP |
ITP |
Age |
Children |
Children |
Young adults |
Children or
adults |
Assoc infection |
Diarrhea (E.
coli) |
URI |
None |
Viral |
RBC |
Low |
N |
Low |
N |
Platelet |
Low |
N |
Low |
Low |
Peripheral smear |
Hemolysis |
N |
Hemolysis |
N |
Kidney
involvement |
ARF, hematuria |
Hematuria |
ARF, proteinuria |
N |
Treatment |
Supportive (dialysis,
transfusions) |
Supportive (dialysis,
transfusions) |
Plasmapheresis,
NSAIDs NO PLATELETS |
Steroids,
splenectomy |
Key points |
Diarrhea |
Rash, abdo pain,
arthritis, melena |
CNS changes |
Antiplatelet
antibodies |
Drug |
Dose |
Side effects |
IVIG |
2g/kg div 2-5 days |
Headache, dermatitis, viral infection, fluid overload, anaphylaxis,
hepatitis, acute renal failure, venous thrombosis, aseptic meningitis |
Plasma exchange |
N/A |
Hematoma, pneumothorax, septicemia, bleeding, cardiovascular
instability, hypocalcemia, blood pressure fluctuations, distal paresthesias |
Corticosteroids |
|
Psychosis, mood disorders, cataracts, acne, striae, thinning of skin,
Cushing’s syndrome (fat pads, moon facies), hypertension, gastritis, gastric
hemorrhage and anemia, hyperphagia, weight gain, osteoporosis, avascular
necrosis of femoral head, immune suppression and opportunistic infections,
gynecomastia, testicular atrophy, hyperglycemia, glucose intolerance |